Céline CAKIR

Céline CAKIR
Professeur des Universités

École Nationale Supérieure d'Agronomie et des Industries Alimentaires
Université de Lorraine

MRCA

Phone

+33 (0)3 72 74 41 58

E-mail

celine.cakir@univ-lorraine.fr

Research programs

• Study of the cellular and molecular mechanisms involved in the toxicity of organochlorine pollutants (CLD and CLD-OH) on liver and adipocyte cells in culture CHLORDEMEC

  Although its use was banned more than 30 years ago, chlordecone (CLD), a persistent organic pollutant, and its metabolite, chlordecol (CLD-OH), are still found in some soils in the French West Indies. Ingested by humans and animals, mainly through food, CLD is responsible for the development of cancer, particularly of the prostate, and neurological disorders. An aldo keto reductase (AKR1C4) in the liver of animals is thought to be responsible for transforming CLD into CLD-OH.

  The aim of this project is to study the cellular and molecular mechanisms involved in the toxicity of CLD and its metabolite, CLD-OH, on liver and adipocyte cells in order to gain a better understanding of their mode of action in vivo.

    

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Last valorisations (2021 - 2025)

• Comparison of the impact of chlordecone and its metabolite chlordecol on genes involved in pesticide metabolism in HepG2 cell line

  2025 Publications

  Baratzhanova, G., El Sheikh Saad, H., Fournier, A., Huguet-Cizo, M., Joubert, O.-L., Paul, A., Djansugurova, L.-E., Cakir, C.

  Environmental Toxicology and Pharmacology, 116 (104701), pp. 1-8.

  HAL DOI

• Characterization and Bioactivities of Gelatin Hydrolysates of Red Tilapia ( Oreochromis spp.) Scale Byproducts

  2025 Publications

  Echavarría, J. A. C., Irankunda, R., Arnoux, P., Mathé, C., Girardet, J-M., Cakir-Kiefer, C., Risler, A., Stefan, L., Paris, C., Montoya, J. E. Z., Selmeczi, K., Canabady-Rochelle, L.

  ACS Food Science & Technology, xxxx (xxx), pp. A-P.

  DOI

• Pisum Sativum protein hydrolysates: Production, Sensitive screening of nickel chelating peptides and evaluation of antioxidant properties

  2025 Publications

  Irankunda, R., Echavarría, J.A.C., El Hajj, S., Paris, C., Al Dakdouki, S., Cakir-Kiefer, C., Girardet, J., Arnoux, P., Muhr, L., Canabady-Rochelle, L.

  Food Bioscience, 66 (106001), pp. 1-13.

  HAL DOI

• The mode of action of different organochlorine pesticides families in mammalians

  2024 Publications

  Baratzhanova, G., Fournier, A., Delannoy, M., Baubekova, A., Altynova, N., Djansugurova, L., Cakir, C.

  Environmental Toxicology and Pharmacology, 110 (104514), pp. 1-12.

  DOI

• Application of the switchSENSE® technology for real-time study of pesticides interaction with biological molecules

  2024 Publications

  Baratzhanova, G., Girardet, J.-M., Fournier, A., Djansugurova, L., Cakir, C.

  BIO Web of Conferences, 100 (03003), pp. 1-7.

  HAL DOI

• Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

  2023 Publications

  Altynova, N., Khamdiyeva, O., Garshin, A., Baratzhanova, G., Amirgaliyeva, A., Seisenbayeva, A., Abylkassymova, G., Yergali, K., Tolebaeva, A., Skvortsova, L., Zhunussova, G., Bekmanov, B., Cakir-Kiefer, C., Djansugurova, L.

  Toxics, 11 (12), (article) 948 (pp. 1-24).

  HAL DOI

• Individual risk assessment for population living on the territories long-term polluted by organochlorine pesticides

  2023 Publications

  Garshin, A., Altynova, N., Djangalina, E., Khamdiyeva, O., Baratzhanova, G., Tolebaeva, A., Zhaniyazov, Z., Khussainova, E., Cakir-Kiefer, C., Jurjanz, S., Delannoy, M., Djansugurova, L.

  Toxics, 11 (6), (article) 482, pp. 1-24.

  HAL DOI

• Encapsulation of Salmon Peptides in Marine Liposomes: Physico-Chemical Properties, Antiradical Activities and Biocompatibility Assays

  2022 Publications

  Hanachi, A., Bianchi, A., Kahn, C.J.-F., Velot, E., Arab-Tehrany, E., Cakir-Kiefer, C., Linder, M.

  Marine Drugs, 20 (4), pp. 1-18

  HAL DOI

• Equine lactoferrin: Antioxidant properties related to divalent metal chelation

  2022 Publications

  Narmuratova, Z., Hentati, F., Girardet, J.-M., Narmuratova, M., Cakir-Kiefer, C.

  LWT - Food Science and Technology, 161, 113426, (pp. 1-8).

  HAL DOI

• Electrically Switchable Nanolever Technology for the Screening of Metal-Chelating Peptides in Hydrolysates

  2021 Publications

  El hajj, S., Sepúlveda Rincón, C.T., Girardet, J.-M., Cakir-Kiefer, C., Stefan, L., Zapata Montoya, J.E., Boschi-Muller, S., Gaucher, C., Canabady-Rochelle, L.

  Journal of Agricultural and Food Chemistry, 69 (31), pp. 8819-8827.

  HAL DOI

• Food protein-derived anxiolytic peptides: potential role in anxiety management

  2021 Publications

  Hafeez, Z., Benoît, S., Cakir-Kiefer, C., Dary, M., Miclo, L.

  Food & Function, 12, pp. 1415-1431.

  HAL DOI

• Metabolomics approach based on LC-HRMS for the fast screening of iron(II)-chelating peptides in protein hydrolysates

  2021 Publications

  Paris, C., Selmeczi, K., Ebel, B., Stefan, L., Csire, G., Cakir-Kiefer, C., Desobry, S., Canabady-Rochelle, L., Chaimbault, P.

  Analytical and Bioanalytical Chemistry, 413 (--), pp. 315-329.

  HAL DOI

• Quality of Beverage Intake and Cardiometabolic and Kidney Outcomes: Insights From the STANISLAS Cohort

  2021 Publications

  Wagner, S., Merkling, T., Girerd, N., Bozec, E., Van den Berghe, L., Hoge, A., Guillaume, M., Kanbay, M., Cakir-Kiefer, C., Thornton, S., Boivin, J.-M., Mercklé, L., Laville, M., Rossignol, P., Nazare, J.-A.

  Frontiers in Nutrition, 8, 738803 (pp. 1-13).

  HAL DOI

• Characterization of the mode of action of chlordecone and chlordecone alcohol using HepG2 cell as model

  2024 Communications

  Baratzhanova, G., El Sheikh Saad, H., Fournier, A., Huguet-Cizo, M., Paul, A., Joubert, O., Djansugurova, L., Cakir, C.

  Journée scientifique de l'école doctorale SIReNa 2024, 05 mars, Vandœuvre-lès-Nancy, France

• Study of the mode of action and toxicity of chlordecone and its metabolite chlordecol using HepG2 cell line

  2023 Communications

  Baratzhanova, G., El Sheikh Saad, H., Fournier, A., Huguet-Cizo, M., Joubert, O., Paul, A., Djansugurova, L., Cakir-Kiefer, C.

  47th FEBS Congress, 08 juillet - 12 septembre, Tours, France

• Caractérisation in vitro de la toxicité et du métabolisme hépatique du chlordécone alcool (chlordécol) sur un modèle cellulaire d’hépatocytes humains HepG2

  2022 Communications

  El Sheikh Saad, H., Baratzhanova, G., Huguet-Cizo, M., Joubert, O., Fournier, A., Cakir-Kiefer, C.

  Rencontre Chlordécone, connaître pour agir, 12-14 décembre, Le Gosier (Guadeloupe), France

• Characterization of the mode of action of chlordecone by in vitro study of the enzymes implicated in its metabolism as well as in hepatic cells HepG2

  2022 Communications

  Baratzhanova, G., Fournier, A., Huguet-Cizo, M., Djansugurova, L., Cakir-Kiefer, C.

  Séminaire annuel de l'école doctorale SIReNa, 08 mars, Vandoeuvre Lès Nancy, France

• SwitchSENSE® approach of small molecule transport through two examples: 1-Exchange of glutathione between two fungal anti-oxidative proteins 2-Binding of a chlorinated pesticide to plasmatic lipoproteins

  2021 Communications

  Girardet, J.-M., Cakir-Kiefer, C., Bchini, R., Morel-Rouhier, M.

  Biophysical Method and switchSENSE User Meeting, 15-17 septembre, Munich, Allemagne

• Chélation des métaux divalents et activités antioxydantes de la lactoferrine équine

  2021 Communications

  Hentati, F., Narmuratova, Z., Girardet, J.-M., Narmuratova, M., Cakir-Kiefer, C.

  2ème Conférence Internationale POLYSAC 2021, 11-13 décembre, SFAX, TUNISIE

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