01/06/2025 - 31/05/2027
Although its use was banned more than 30 years ago, chlordecone (CLD), a persistent organic pollutant, and its metabolite, chlordecol (CLD-OH), are still found in some soils in the French West Indies. Ingested by humans and animals, mainly through food, CLD is responsible for the development of cancer, particularly of the prostate, and neurological disorders. An aldo keto reductase (AKR1C4) in the liver of animals is thought to be responsible for transforming CLD into CLD-OH.
The aim of this project is to study the cellular and molecular mechanisms involved in the toxicity of CLD and its metabolite, CLD-OH, on liver and adipocyte cells in order to gain a better understanding of their mode of action in vivo.
