Marion HUGUET-CIZO
Technicien(ne)
École Nationale Supérieure d'Agronomie et des Industries Alimentaires
Université de Lorraine
MRCA Phone
+33 (0)3 72 74 41 56 CABARETox is a research project of the MRCA team carried out in collaboration with the OFB (Office Français de la Biodiversité) and the ANSES (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail).
This project follows on from the CABARET project, which highlighted the presence of numerous transformation products (TPs) of Phyto-Pharmaceutical Products (PPPs) in the aquatic ecosystems of the headwaters of basins at concentrations often higher than those of their parent molecules. Among these ecosystems exposed to PPPs and TPs, ponds are home to a large biodiversity (avifauna, ichthyofauna, batrachians, etc.) likely to be exposed to these contaminants.
CABARETox will aim to provide information on the toxicity of the PTs most commonly encountered and to assess the health status of aquatic organisms in ponds located in catchment areas selected on the basis of a PPP exposure gradient.
This project, under the scientific coordination of Damien Banas, is positioned at the heart of URAFPA's "water-contaminant" transversal action.
More infos
Although its use was banned more than 30 years ago, chlordecone (CLD), a persistent organic pollutant, and its metabolite, chlordecol (CLD-OH), are still found in some soils in the French West Indies. Ingested by humans and animals, mainly through food, CLD is responsible for the development of cancer, particularly of the prostate, and neurological disorders. An aldo keto reductase (AKR1C4) in the liver of animals is thought to be responsible for transforming CLD into CLD-OH.
The aim of this project is to study the cellular and molecular mechanisms involved in the toxicity of CLD and its metabolite, CLD-OH, on liver and adipocyte cells in order to gain a better understanding of their mode of action in vivo.
Baratzhanova, G., El Sheikh Saad, H., Fournier, A., Huguet-Cizo, M., Joubert, O.-L., Paul, A., Djansugurova, L.-E., Cakir, C.
Environmental Toxicology and Pharmacology, 116 (104701), pp. 1-8.
Conseil, G., Cardoso, O., Felten, V., Rosin, C., Pasquini, L., Huguet-Cizo, M., Milla, S., Banas, D.
Ecotoxicology and Environmental Safety, 295 (-), pp. 118-143.
Ben mihoub, A.-M., Elkhoury, K.-A., Nel, J.-A., Acherar, S.-A., Velot, E.-M., Malaplate, C.-A., Linder, M.-I., Latifi, S.-H., Kahn, C.-Y., Huguet-Cizo, M., T. Yen, F.-R., Arab-tehrany, E.-L.
Pharmaceutics, 15 (12), 2665
Passeri, E., Elkhoury, K., Jimenez Garavito, M.C., Desor, F., Huguet-Cizo, M., Soligot-Hognon, C., Linder, M., Malaplate, C., Yen, F.T., Arab-Tehrany, E.
International Journal of Molecular Sciences, 22 (21), pp. 11859.
Baratzhanova, G., El Sheikh Saad, H., Fournier, A., Huguet-Cizo, M., Paul, A., Joubert, O., Djansugurova, L., Cakir, C.
Journée scientifique de l'école doctorale SIReNa 2024, 05 mars, Vandœuvre-lès-Nancy, France
Baratzhanova, G., El Sheikh Saad, H., Fournier, A., Huguet-Cizo, M., Joubert, O., Paul, A., Djansugurova, L., Cakir-Kiefer, C.
47th FEBS Congress, 08 juillet - 12 septembre, Tours, France
Delannoy, M., Le Roux, Y., Gaspard, S., Fournier, A., Hartmeyer, P., Huguet-Cizo, M., Soligot-Hognon, C., Jurjanz, S., Piutti, S., Rychen, G., Feidt, C.
Rencontres Chlordécone, connaître pour agir, 12-14 décembre, Le Gosier (Guadeloupe), France
El Sheikh Saad, H., Baratzhanova, G., Huguet-Cizo, M., Joubert, O., Fournier, A., Cakir-Kiefer, C.
Rencontre Chlordécone, connaître pour agir, 12-14 décembre, Le Gosier (Guadeloupe), France
Stephan, P., Amutova, F., Le Roux, Y., Gaspard, S., Feidt, C., Huguet-Cizo, M., Hartmeyer, P., Soligot-Hognon, C., Jurjanz, S., Rychen, G., Delannoy, M.
Rencontres Chlordécone, connaître pour agir, 12-14 décembre, Le Gosier (Guadeloupe), France
Stephan, P., Le Roux, Y., Gaspard, S., Michaux, F., Feidt, C., Huguet-Cizo, M., Hartmeyer, P., Soligot-Hognon, C., Rychen, G., Delannoy, M.
Rencontes Chlordécone, connaître pour agir, 12-14 décembre, Le Gosier (Guadeloupe), France
Baratzhanova, G., Fournier, A., Huguet-Cizo, M., Djansugurova, L., Cakir-Kiefer, C.
Séminaire annuel de l'école doctorale SIReNa, 08 mars, Vandoeuvre Lès Nancy, France
